Combining quantitative proteomics data processing workflows for greater sensitivity.

We here describe a normalization method to combine quantitative proteomics data. By merging the output of two popular quantification software packages, we obtained a 20% increase (on average) in the number of quantified human proteins without suffering from a loss of quality. Our integrative workflow is freely available through our user-friendly, open-source Rover software (http://compomics-rover.googlecode.com/).

Colaert N, Van Huele C, Degroeve S, Staes A, Vandekerckhove J, Gevaert K, Martens L. Combining quantitative proteomics data processing workflows for greater sensitivity. Nat Methods. 2011 May 8. [Epub ahead of print]

pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21552256

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