The identification of proteins by mass spectrometry is a standard technique in the field of proteomics, relying on search engines to perform the identifications of the acquired spectra. Here, we present a user-friendly, lightweight and open-source graphical user interface called SearchGUI (http://searchgui.googlecode.com), for configuring and running the freely available OMSSA (open mass spectrometry search algorithm) and X!Tandem search engines simultaneously. Freely available under the permissible Apache2 license, SearchGUI is supported on Windows, Linux and OSX.
Vaudel M, Barsnes H, Berven FS, Sickmann A, Martens L. ‘SearchGUI: An open-source graphical user interface for simultaneous OMSSA and X!Tandem searches‘. Proteomics. 2011 Mar;11(5):996-9.